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Cole-Parmer Freeze Dryers

Cole-Parmer offers a range of benchtop freeze dryers that are available with system capacities from 1L, 2.5L, 4.5L and 6.5L. Upon request with our technical staff we are able to offer console sizes up to 18L in capacities. Our range in freeze dryers include variations in refrigerator collectors that cool to -50°C and -84°C as well as PTFE-coated models for more corrosive compounds. Our freeze dry systems are designed to handle the lyophilization needs of research and pilot plant laboratories, with the lower temperature collectors ideal for freeze drying samples with low eutectic temperature.

Freeze drying involves the removal of water or other solvents from a frozen product. Freeze dryers carry out three steps for this process - prefreezing, primary drying and finally secondary drying. Freeze drying has been used in a number of applications however it is most commonly used in the pharmaceutical industry, for example stabilization of living material such as microbial cultures, preservation of animal specimens and the concentration and recovery of reaction products. Once freeze dried properly, products do not need refrigeration and items can be stored at ambient temperatures.

To complete your freeze drying systems, you will require the following components:

  • Freeze Dryer - Cole-Parmer's catalog range carries capacities up to 6L with temperatures of -54°C and -84°C, however larger capacities of up to 18L are available upon request.

 

  • Drying System Platforms - Depending on your application, Cole-Parmer's freeze dryers offer a range of drying platforms. The drying platforms are the interfacing device that conducts solvent from the sample to the freeze dryer and may connect or hold sample containers.

Chamber platform

Either accommodates sample shelving or provides flexible port connectivity for up to 12 or 16 sample flasks. Shelves maybe used for either bulk samples or bottles and are available with heaters to accelerate the freeze drying process.

Manifold

For parallel lyophilization of small sample volumes and products with high eutectic and collapse temperatures. Sample is prefrozen and then attached to the manifold with vacuum so that the product is not warmed. This process allows for samples of different makeup and size to be attached to the system, and for the sample to be removed from the manifold as the product is dried.

 

Stoppering Tray Dryer

For batches of small vessels or bulk sample on shelves. Ideal for preparing a large quantity of vials containing the same sample. The samples can be prefrozen directly on the shelf of the tray dryer. This method ensures that all samples are handled alike, also allowing sample vials to be vacuum sealed in situ at the same time and under the same conditions.

 

 

  • Vacuum Pump - Providing an environment that allows for easy removal of water molecules from the sample is critical to successful freeze drying. A vacuum pump is needed to lower the pressure around the product being freezed. Select from standard or chemical resistant models to enable freeze drying with more aggressive solvents

 

  • Sample containers - Sturdy, borosilicate glass vessels options include flasks, serum bottles, vials, and ampules

 

Add this option:

  • Shell Freezer - for preliminary freezing of samples. Improves freeze drying efficiency by maximizing sample surface area in cylindrical fast free flasks. Available as stand-alone or integrated unit.

Typical Application for freeze dryers

  • Freeze Drying Fish Samples for Volatile Substances
  • General Freeze Dry Application for Snake Venom
  • Freeze Drying Fungi
  • General Freeze Dry Application for Monitoring Soil Samples
  • Freeze Dry Applications for Monitoring Anti-Cancer Drugs
  • Freeze Drying Mango Powder